Мастерство обучения гарантирует правильное использование средств индивидуальной защиты при моделировании клинических встреч с COVID-19

Введение: Правильное использование средств индивидуальной защиты (СИЗ) ограничивает передачу серьезных инфекционных заболеваний медицинским работникам, что критически важно в эпоху коронавирусной болезни 2019 г. (COVID-19).

Однако предыдущие исследования показали, что медицинские работники часто ошибаются при применении и снятии СИЗ. Цель этого исследования состояла в том, чтобы определить, улучшают ли основанное на моделировании, освоение навыков обучения с осознанной практикой правильное использование СИЗ врачами во время имитации клинического контакта с пациентом COVID-19.

Методы:
• Это было предварительное и последующее исследование, проведенное в отделении неотложной помощи крупной академической больницы третичного уровня с 31 марта по 8 апреля 2020 года. В нем приняли участие 117 субъектов, в том числе 56 преподавателей и 61 врач-ординатор.

Перед вмешательством все участники прошли обучение по требованию учебного заведения по использованию СИЗ с помощью онлайн-видео и дополнительных материалов.

• Участники выполнили предварительную оценку навыков с использованием контрольного списка из 21 пункта, в котором указаны шаги по правильному надеванию и снятию СИЗ. Ожидается, что участники получат минимальный проходной балл (MPS) в 100%, определенный группой экспертов с использованием методик установления стандартов Mastery Angoff и Patient Safety. Участники, которые встретились с MPS на предварительном тестировании, были освобождены от образовательного вмешательства.

• Тестирование проводилось до и после личной демонстрации правильной техники надевания и снятия и 20 минут сознательной практики. Первичным результатом было изменение оценок правильного использования СИЗ после нашего образовательного вмешательства.

Вторичные результаты включали различия в показателях успеваемости между преподавателями и врачами-резидентами, а также различия в показателях работы при надевании и снятии.

Результаты. Все участники имели средний балл до тестирования 73,1% (95% доверительный интервал [ДИ], 70,9-75,3%). Результаты предварительного тестирования преподавателей и резидентов были схожими (75,1% против 71,3%, p = 0,082).

Средние баллы за снятие предметов перед тестированием были ниже, чем баллы за надевание, у всех участников (65,8% против 82,8%, p <0,001). Баллы участников увеличились на 26,9% (95% ДИ разницы 24,7-29,1%, p <0,001) после нашего образовательного вмешательства, в результате чего все участники достигли 100% MPS.

Заключение: Вмешательство в овладение мастерством с осознанной практикой обеспечило правильное использование СИЗ субъектами врачей в симулированной клинической встрече с пациентом COVID-19. Необходимо дальнейшее изучение результатов трансляции.

Human anti-Human IL-4 mAb
MBS8576802-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-4 mAb
MBS8576802-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Polyclonal Anti- human IL-4 Antibody
GWB-BBP010	GenWay Biotech	0.1 mg	Ask for price

human anti-human IL-4 mAb (12)
E4A09D04-12	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (52)
E4A09D04-52	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (C1)
E4A09D04-C1	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396740-01mg	MyBiosource	0.1mg	EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396740-5x01mg	MyBiosource	5x0.1mg	EUR 1015

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396742-01mg	MyBiosource	0.1mg	EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396742-5x01mg	MyBiosource	5x0.1mg	EUR 1015

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396744-01mg	MyBiosource	0.1mg	EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396744-5x01mg	MyBiosource	5x0.1mg	EUR 1015

Anti-Human IL-4
GWB-BIG229	GenWay Biotech	500ug	Ask for price

Anti-Human IL-4
MBS550674-01mg	MyBiosource	0.1mg	EUR 260

Anti-Human IL-4
MBS550674-02mg	MyBiosource	0.2mg	EUR 335

Anti-Human IL-4
MBS550686-01mg	MyBiosource	0.1mg	EUR 260

Anti-Human IL-4
MBS550686-02mg	MyBiosource	0.2mg	EUR 335

Anti‐Human IL‐17A
E2790213	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

IL-4， Human
E34M006H	EnoGene	5 μg	EUR 155

Human IL-4
GWB-CB2917	GenWay Biotech	0.01 mg	Ask for price

Human IL-4
gAP-0227	Angio Proteomie	1mg	EUR 450

Human IL-4
MBS691496-0002mg	MyBiosource	0.002mg	EUR 225

Human IL-4
MBS691496-5x0002mg	MyBiosource	5x0.002mg	EUR 725

Human IL-4
MBS691811-005mg	MyBiosource	0.05mg	EUR 555

Human IL-4
MBS691811-5x005mg	MyBiosource	5x0.05mg	EUR 2205

Human IL-4
MBS691915-001mg	MyBiosource	0.01mg	EUR 265

Human IL-4
MBS691915-5x001mg	MyBiosource	5x0.01mg	EUR 890

IL-4, Human
MBS8575163-0005mg	MyBiosource	0.005mg	EUR 245

IL-4, Human
MBS8575163-5x0005mg	MyBiosource	5x0.005mg	EUR 940

Anti-Human IL-4 Antibody
101-M05	ReliaTech	500 µg	EUR 246.75
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody
101-M508	ReliaTech	100 µg	EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody
102-P34	ReliaTech	100 µg	EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-human IL-4 antibody
STJ15100045	St John's Laboratory	250 µg	EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti-human IL-4 antibody
STJ15100046	St John's Laboratory	250 µg	EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Human Interleukin-4 (IL-4) Antibody
32184-05111	AssayPro	150 ug	EUR 215

Anti-Human IL-4 PE
MBS697227-100Tests	MyBiosource	100Tests	EUR 360

Anti-Human IL-4 PE
MBS697227-25Tests	MyBiosource	25Tests	EUR 215

Anti-Human IL-4 PE
MBS697227-5x100Tests	MyBiosource	5x100Tests	EUR 1580

Anti-Human IL-4 PE
MBS697234-100Tests	MyBiosource	100Tests	EUR 335

Anti-Human IL-4 PE
MBS697234-25Tests	MyBiosource	25Tests	EUR 185

Anti-Human IL-4 PE
MBS697234-5x100Tests	MyBiosource	5x100Tests	EUR 1475

Anti-Human IL-4 APC
MBS697235-100Tests	MyBiosource	100Tests	EUR 320

Anti-Human IL-4 APC
MBS697235-25Tests	MyBiosource	25Tests	EUR 185

Anti-Human IL-4 APC
MBS697235-5x100Tests	MyBiosource	5x100Tests	EUR 1395

Mouse Anti-Human IL-4
MBS690917-05mg	MyBiosource	0.5mg	EUR 525

Mouse Anti-Human IL-4
MBS690917-5x05mg	MyBiosource	5x0.5mg	EUR 2080

Human Interleukin-4 (IL-4)
1-CSB-EP011659HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
MW: 31 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

Interleukin-4 (IL-4) Human
GWB-2A39E4	GenWay Biotech	0.01 mg	Ask for price
Interleukin-4 (IL-4) Human was previously known under catalogue number 10-251-407123 was previously known under catalogue number 10-251-407123

IL-4, Interleukin-4, human
RC212-15	Bio Basic	5ug	EUR 125.26
Product category: Proteins/Recombinant Proteins/Cytokines

human anti-human IL-2 mAb
E409C12-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb
E409C14-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb
E409C16-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb
E4A09D05	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

Human anti-Human IL-2 mAb
MBS8576800-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-2 mAb
MBS8576800-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-5 mAb
MBS8576804-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-8 mAb
MBS8576808-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

human anti-human IL-1β mAb
E409C11-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb
E409C17-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

Human anti-Human IL-10 mAb
MBS8576810-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-10 mAb
MBS8576810-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

rec IL-4 (human)
H-9630.0002	Bachem	2.0µg	EUR 313.2

rec IL-4 (human)
H-9630.0010	Bachem	10.0µg	EUR 1140

human anti-human IL-12/IL-23 p40 mAb(3H2)
E4A09D33-3H2	EnoGene	50ug	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)
E4A09D33-5N9	EnoGene	50ug	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PE Anti-Human IL-4 Antibody
DL22181F-20Tests	DL Develop	20Tests	EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody
DL22181F-50Tests	DL Develop	50Tests	EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody
RD22181F-100Tests	Reddot Biotech	100Tests	EUR 285
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody
RD22181F-100Testsx2	Reddot Biotech	100Testsx2	EUR 427.5
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody
RD22181F-20Tests	Reddot Biotech	20Tests	EUR 112.5
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody
DL22182F-20Tests	DL Develop	20Tests	EUR 245
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody
DL22182F-50Tests	DL Develop	50Tests	EUR 357.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Rat Anti-Human IL-4, Antibody
GWB-600465	GenWay Biotech	0.5 mg	Ask for price

Rat Anti-Human IL-4, Antibody
GWB-ACBDBA	GenWay Biotech	0.5 mg	Ask for price

Rat Anti-Human IL-4, Antibody
GWB-C54D97	GenWay Biotech	0.5 mg	Ask for price

APC Anti-Human IL-4 Antibody
RD22182F-100Tests	Reddot Biotech	100Tests	EUR 330
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody
RD22182F-100Testsx2	Reddot Biotech	100Testsx2	EUR 495
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody
RD22182F-20Tests	Reddot Biotech	20Tests	EUR 135
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

human anti-human IL-12/IL-23 p40 mAb(1G11)
E4A09D33-1G11	EnoGene	50ug	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FITC Anti-Human IL-4 Antibody
DL22180F-20Tests	DL Develop	20Tests	EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

FITC Anti-Human IL-4 Antibody
DL22180F-50Tests	DL Develop	50Tests	EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

FITC Anti-Human IL-4 Antibody
RD22180F-100Tests	Reddot Biotech	100Tests	EUR 285
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

FITC Anti-Human IL-4 Antibody
RD22180F-100Testsx2	Reddot Biotech	100Testsx2	EUR 427.5
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

FITC Anti-Human IL-4 Antibody
RD22180F-20Tests	Reddot Biotech	20Tests	EUR 112.5
ICFCM
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Anti-Human IL-4-UNLB Antibody
MBS4152544-01mg	MyBiosource	0.1mg	EUR 535

Anti-Human IL-4-UNLB Antibody
MBS4152544-5x01mg	MyBiosource	5x0.1mg	EUR 2145

Purified Anti-Human IL-4 Antibody
DL22179F-100ug	DL Develop	100μg	EUR 290
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Purified Anti-Human IL-4 Antibody
DL22179F-25ug	DL Develop	25μg	EUR 177.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Purified Anti-Human IL-4 Antibody
RD22179F-100ug	Reddot Biotech	100μg	EUR 120
ICFCM,ELISA
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Purified Anti-Human IL-4 Antibody
RD22179F-25ug	Reddot Biotech	25μg	EUR 75
ICFCM,ELISA
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Human IL-4 Protein
abx060798-20ug	Abbexa	20 ug	EUR 560.4
Shipped within 5-10 working days.

Human IL-4 protein
PRP100273-100ug	Abbkine	100 μg	EUR 1029
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein
PRP100273-1mg	Abbkine	1 mg	EUR 7139
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein
PRP100273-20ug	Abbkine	20 μg	EUR 509
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein
PRP2017-100ug	Abbkine	100 μg	EUR 429
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein
PRP2017-10ug	Abbkine	10 μg	EUR 59
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein
PRP2017-1mg	Abbkine	1 mg	EUR 3739
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein
PRP2017-50ug	Abbkine	50 μg	EUR 249
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein
MBS9719248-001mg	MyBiosource	0.01mg	EUR 115

Human IL-4 protein
MBS9719248-005mg	MyBiosource	0.05mg	EUR 225

Human IL-4 protein
MBS9719248-01mg	MyBiosource	0.1mg	EUR 325

Human IL-4 protein
MBS9719248-1mg	MyBiosource	1mg	EUR 2485

Human IL-4 protein
MBS9719248-5x1mg	MyBiosource	5x1mg	EUR 11130

Human IL-4 Protein
MBS9718706-0005mg	MyBiosource	0.005mg	EUR 135

Human IL-4 Protein
MBS9718706-002mg	MyBiosource	0.02mg	EUR 285

Human IL-4 Protein
MBS9718706-01mg	MyBiosource	0.1mg	EUR 720

Human IL-4 Protein
MBS9718706-1mg	MyBiosource	1mg	EUR 3925

Human IL-4 Protein
MBS9718706-5x1mg	MyBiosource	5x1mg	EUR 17610

Recombinant Human IL-4
6486	Immunochemistry	5 µg	EUR 194

IL-4, human recombinant
4137-10	Biovision	each	EUR 333.6

IL-4, human recombinant
4137-1000	Biovision	each	EUR 4444.8

IL-4, human recombinant
4137-50	Biovision	each	EUR 836.4

Recombinant human IL-4
rcyec-hil4	InvivoGen FR	10 µg	EUR 156.45

Recombinant Human IL-4
HEILP-0401	Cyagen	5ug	Ask for price

Recombinant Human IL-4
SJB02-03	Amyotop	10µg/vial	EUR 342

Recombinant Human IL-4
SJB02-05	Amyotop	100µg/vial	EUR 864

Recombinant Human IL-4
SJB02-06	Amyotop	30µg/vial	EUR 516

Recombinant Human IL-4
MBS7614313-005mg	MyBiosource	0.05mg	EUR 345

Recombinant Human IL-4
MBS7614313-02mg	MyBiosource	0.2mg	EUR 635

Recombinant Human IL-4
MBS7614313-1mg	MyBiosource	1mg	EUR 1800

Recombinant Human IL-4
MBS7614313-5x1mg	MyBiosource	5x1mg	EUR 6955

Recombinant Human IL-4
MBS7609188-005mg	MyBiosource	0.05mg	EUR 345

Recombinant Human IL-4
MBS7609188-02mg	MyBiosource	0.2mg	EUR 635

Recombinant Human IL-4
MBS7609188-1mg	MyBiosource	1mg	EUR 1800

Recombinant Human IL-4
MBS7609188-5x1mg	MyBiosource	5x1mg	EUR 6955

Human IL-4, Recombinant
MBS319039-002mg	MyBiosource	0.02mg	EUR 330

Human IL-4, Recombinant
MBS319039-5x002mg	MyBiosource	5x0.02mg	EUR 1385

Recombinant Human IL-4
MBS258217-0005mg	MyBiosource	0.005mg	EUR 305

Recombinant Human IL-4
MBS258217-5x0005mg	MyBiosource	5x0.005mg	EUR 1210

Recombinant Human IL-4
P1121-.005	ApexBio	5ug	EUR 108.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human IL-4
P1121-.1	ApexBio	100ug	EUR 976
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human IL-4
P1121-.5	ApexBio	500ug	EUR 2189.6
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human IL-4
PH2006-.01	ApexBio	10ug	EUR 224
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human IL-4
PH2006-.1	ApexBio	10X10ug	EUR 684.8
Description: Peptides & Proteins|Recombinant Proteins

mAb mouse anti-human IL-4
CT253	U-CyTech	0.5 mg	EUR 312

mouse anti-human IL-4 mAb
E409C13-m100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

Mouse anti-Human IL-4 mAb
MBS8576803-005mg	MyBiosource	0.05mg	EUR 325

Mouse anti-Human IL-4 mAb
MBS8576803-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Mouse anti-Human IL-4 mAb
MBS8576803-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Mouse anti-Human IL-4 mAb
MBS8576803-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Mouse anti-Human IL-4 mAb
MBS8576803-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Размышления врачей-интернов об их обучении использованию средств индивидуальной защиты

История вопроса: Текущая пандемия COVID-19 продемонстрировала, что средства индивидуальной защиты (СИЗ) необходимы для предотвращения заражения и передачи инфекционных заболеваний, однако их использование в клинических условиях часто не оптимально.

Обучение и образование важны для обеспечения и поддержания безопасного и эффективного использования СИЗ медицинскими интернами, но существующие методы часто неадекватны для обеспечения соответствующих знаний и навыков.

Целью этого исследования было изучить опыт выпускников медицинских вузов по использованию СИЗ и выявить возможности для улучшения образовательных и учебных программ с целью повышения профессиональной безопасности и безопасности пациентов.

Методы: это исследование было проведено в 2018 году в крупной клинической больнице третичного уровня в Сиднее, Австралия, для изучения собственного опыта использования СИЗ медицинскими стажерами в начале их стажировки.

Рефлексивные группы были собраны сразу после теоретического и практического обучения СИЗ, во время ориентации в больнице. Стенограммы записанных дискуссий были проанализированы с использованием тематического подхода, основанного на модели поведения COM-B (способность, возможность, мотивация – поведение).

Результаты: приняли участие 80% из 90 подходящих выпускников. Многие стажеры ранее не получали формального обучения специальным навыкам, необходимым для оптимального использования СИЗ, и выработали потенциально небезопасные привычки.

Их опыт студентов-медиков в клинических областях резко контрастировал с рекомендуемой практикой, преподаваемой в больницах, и повлиял на их способность культивировать правильное использование СИЗ.

Выводы: обучение в бакалавриате должно соответствовать передовой практике использования СИЗ и включать практическое обучение, включающее правильные и безопасные методы.

Прогностическая ценность сверхэкспрессии ферментов, связанных с метаболизмом жирных кислот, при плоскоклеточном раке головы и шеи

Перепрограммирование метаболизма подвижных жизненных сил, соответствующего метаболизму липидов, является индикатором плоскоклеточного рака вершины и шеи (SCCHN). Тем не менее, остается неясным, влияет ли экспрессия белка, связанная с окислением жирных кислот (FAO) на выживаемость в SCCHN.

Мы стремились проанализировать экспрессию ферментов, связанных с ФАО, и определить ее корреляцию с клинико-патологическими переменными у пациентов с SCCHN. Иммуногистохимическая оценка (ИГХ) экспрессии белка, связанного с ФАО, вместе с карнитин-пальмитоилтрансферазой 1 (СРТ1), ацил-КоА-дегидрогеназой и синтазой жирных кислот (FAS) была проведена с использованием тканевых микрочипов из 102 резецированных опухолей SCCHN.

Выражения были классифицированы в соответствии с оценками IHC, и была решена статистическая принадлежность к клинико-патологическим компонентам. Относительно высокой экспрессии длинноцепочечной ацил-КоА-дегидрогеназы (LCAD) была защитная функция от смерти, связанной с раком (скорректированное отношение рисков (HR), 0,2; 95% доверительный интервал (CI), 0,05-0,87) после ковариации корректирование.

Возраст и медицинская стадия оставались объективными предикторами выживаемости (скорректированный HR, 1,75; 95% ДИ, 1,22–2,49 для возраста; скорректированный HR, 14,33; 95% ДИ, 1,89-108,60 для стадии III / IV).
Сверхэкспрессия ацил-CoA дегидрогеназы со средней длиной цепи и FAS коррелировала с высшей стадией опухоли (T3 / T4); тем не менее, ни один из этих компонентов не был объективным предиктором выживаемости.

Было повышено количество ферментов, связанных с ФАО, и сверхэкспрессия LCAD оказала защитное влияние на общую выживаемость у пациентов с более сильным SCCHN. Экспрессия ферментов, связанных с ФАО, может потребовать прогноза по результатам выживаемости при SCCHN.

 

Паклитаксел подавляет миграцию клеток злокачественной глиомы CD133 + U251 за счет снижения экспрессии гликолитических ферментов.

• Жизнеспособное метаболическое перепрограммирование (EMR) позволяет перестраивать последовательность метаболических генов и белков, когда опухолевые клетки адаптируются к своему микроокружению.

EMR характеризуется модификациями метаболического образца и промежуточных продуктов метаболизма, чтобы удовлетворить потребности опухолевых клеток в его или ее злокачественном разрастании и инфильтративном прогрессе.

• В текущем исследовании изучалась функция паклитаксела в низких дозах (PTX) в изменении диапазонов экспрессии ключевых генов и белков в процессе гликолиза в клетках глиомы CD133 + U251 и изучались связанные механизмы регуляции движения на молекулярном уровне.

Иммуномагнитные шарики CD133 были использованы для злокачественных клеток глиомы CD133 + U251, которые затем были разделены прямо на группу, подвергшуюся вредному лечению, и экспериментальную группу, обработанную 1, 2, 4 или 8 мкМ PTX в течение 72 часов.

• Пакет для подсчета клеток-8 (CCK-8) использовался для измерения пролиферации клеток U251. РНК и белок были извлечены из клеток злокачественной глиомы во всех группах, чтобы наблюдать за изменениями в диапазонах экспрессии ключевых гликолитических ферментов, соответствующих переносчику глюкозы 1 (GLUT1), пируваткиназе M (PKM) и лактатдегидрогеназе A (LDHA), используя количественная ПЦР с обратной транскрипцией и вестерн-блоттинг.

Для количественной оценки результатов разрешения РТХ на клетках U251 были проведены анализы миграции через лунки. Клетки глиомы CD133 + U251 удалялись эффективно.

• Клетки CD1133 + имели лучшую цену пролиферации по сравнению с клетками CD1133-. В клетках CD1133 +, обработанных PTX, дозозависимая скидка в пределах диапазонов экспрессии важных гликолитических ферментов GLUT1, PKM и LDHA была замечена в каждом диапазоне мРНК и белка.

Разрешение PTX дополнительно ингибировало миграцию клеток. Различия между управляющими и экспериментальными группами были статистически значимыми (P <0,05).

• Поскольку гликолиз выполняет незаменимую функцию в пролиферации и миграции клеток глиомы, подобных стволовым, PTX может ингибировать прогрессирование опухолевых клеток путем подавления диапазонов экспрессии генов и белков гликолитических ферментов в клетках глиомы CD133 +.

 

Human Dkk-1
MBS692271-5x002mg	MyBiosource	5x0.02mg	EUR 1325

Dkk-1 (Human) ELISA Kit
EKA52037-5x96T	Biomatik Corporation	5x96T	Ask for price

Dkk-1 (Human) ELISA Kit
EKA52037-96T	Biomatik Corporation	96T	EUR 446.9

Human CellExp? DKK-1, Human Recombinant
7132-10	Biovision	each	EUR 333.6

Human CellExp? DKK-1, Human Recombinant
7132-50	Biovision	each	EUR 1358.4

Human Dkk-1 ELISA KIT
E42EH-269	EnoGene	96T/48T	Ask for price

Human Dkk-1 ELISA Kit
E28L0566	EnoGene	96T	EUR 666.67

Human DKK-1 ELISA Kit
EK5390	SAB	96 tests	EUR 599
https://www.sabbiotech.com/g-138088-Human-DKK-1-ELISA-Kit-EK5390.html

Human DKK-1 ELISA KIT
EF000090	Nova Lifetech	96tests	EUR 566

Human Dkk-1 ELISA Kit
GWB-SKR221	GenWay Biotech	96 Tests	Ask for price

Human DKK-1 ELISA kit
LF-EK50797	Abfrontier	1×96T	EUR 777.6

DKK-1 (HEK293-expressed), Human
HY-P7155A	MedChemExpress	50ug	EUR 1011.6

human Dkk-1 Recombinant Protein
100-407	ReliaTech	10 µg	EUR 196.35
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

human Dkk-1 Recombinant Protein
100-407S	ReliaTech	2 µg	EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein
200-013	ReliaTech	20 µg	EUR 136.5
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein
200-013S	ReliaTech	5 µg	EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Recombinant Human DKK-1 Protein
PROTO94907-3	BosterBio	10ug	EUR 380.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Human Dkk-3
MBS691794-0002mg	MyBiosource	0.002mg	EUR 300

Human Dkk-3
MBS691794-001mg	MyBiosource	0.01mg	EUR 450

Human Dkk-3
MBS691794-5x001mg	MyBiosource	5x0.01mg	EUR 1725

Human Dkk-2
MBS692245-0002mg	MyBiosource	0.002mg	EUR 300

Human Dkk-2
MBS692245-001mg	MyBiosource	0.01mg	EUR 450

Human Dkk-2
MBS692245-5x001mg	MyBiosource	5x0.01mg	EUR 1725

Human Dkk-2
MBS692272-0005mg	MyBiosource	0.005mg	EUR 250

Human Dkk-2
MBS692272-002mg	MyBiosource	0.02mg	EUR 360

Human Dkk-2
MBS692272-5x002mg	MyBiosource	5x0.02mg	EUR 1325

Dkk-1 (Human) LumiAb ELISA Kit
MBS9510975-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 4355

Dkk-1 (Human) LumiAb ELISA Kit
MBS9510975-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2225

Dkk-1 (Human) LumiAb ELISA Kit
MBS9510975-96StripWells	MyBiosource	96-Strip-Wells	EUR 500

Dkk-1 (Human) OmniKine ELISA Kit
MBS9502047-1x96Wells	MyBiosource	1x96Wells	EUR 500

Dkk-1 (Human) OmniKine ELISA Kit
MBS9502047-5x96Wells	MyBiosource	5x96Wells	EUR 2300

Dkk-1 (Human) Sandwich ELISA Kit
OK-0326	Assay Biotech	1Kit	EUR 280
Description: Dkk-1 (Human) Colorimetric Sandwich ELISA Kit

Human DKK-1 PicoKine ELISA Kit
EK0867	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human DKK-1 PicoKine ELISA Kit
MBS176546-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2755

Human DKK-1 PicoKine ELISA Kit
MBS176546-96StripWells	MyBiosource	96-Strip-Wells	EUR 600

Human DKK Antibody
E63C02401	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

Human DKK Antibody
MBS857428-01mg	MyBiosource	0.1mg	EUR 305

Human DKK Antibody
MBS857428-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

Human DKK Antibody
MBS857428-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

Human DKK Antibody
MBS857428-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

Human DKK Antibody
MBS857428-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

Active Recombinant Human Dkk-1 Protein
RP01343	Abclonal	100μg	EUR 162.5
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway Show more

Human DKK-1 Recombinant Protein Lyophilized
IHUDKK1RLY2UG	Innovative research	each	EUR 341
Wet Ice
Description: Human DKK-1 Recombinant Protein Lyophilized

Human DKK-1 Recombinant Protein Lyophilized
MBS8431839-INQUIRE	MyBiosource	INQUIRE	Ask for price

Human DKK-1 ELISA kit (4×96T)
LF-EK50798	Abfrontier	4×96T	EUR 2641.2

Nori® Human DKK-1 ELISA Kit
GR106268	Genorise Scientific	96-well	EUR 461

Dkk-1
GT30000	Neuromics	50 ug	EUR 631.2

Dkk-1
MBS555901-005mg	MyBiosource	0.05mg	EUR 610

Dkk-1
MBS555901-5x005mg	MyBiosource	5x0.05mg	EUR 2590

OKAG00221-96W - Dkk-1 ELISA Kit (Human)
OKAG00221-96W	Aviva Systems Biology	1plate:12x8-WellMicrostrips	EUR 475
Dkk-1 ELISA Kit (Human)

OKRC00363-96W - Dkk-1 ELISA Kit (Human)
OKRC00363-96W	Aviva Systems Biology	96Wells	EUR 525
Dkk-1 ELISA Kit (Human)

Dkk-1, 32-266aa, Human, His tag, Baculovirus
MBS203274-001mg	MyBiosource	0.01mg	EUR 375

Dkk-1, 32-266aa, Human, His tag, Baculovirus
MBS203274-005mg	MyBiosource	0.05mg	EUR 1265

Dkk-1, 32-266aa, Human, His tag, Baculovirus
MBS203274-5x005mg	MyBiosource	5x0.05mg	EUR 5460

Human DKK Antibody-HRP
E63C02402	EnoGene	100ug/100ul	EUR 275
Description: Available in various conjugation types.

Human DKK Antibody-HRP
MBS857208-01mg	MyBiosource	0.1mg	EUR 345

Human DKK Antibody-HRP
MBS857208-5x01mg	MyBiosource	5x0.1mg	EUR 1410

Recombinant Human DKK1/Dkk-1 Protein (His Tag)
PKSH033697-10ug	Elabscience Biotech	10ug	EUR 178
> 95 % as determined by reducing SDS-PAGE.
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)
PKSH033697-50ug	Elabscience Biotech	50ug	EUR 523
> 95 % as determined by reducing SDS-PAGE.
Description: Human

Recombinant Human DKK1 / Dkk-1 Protein (His tag)
MBS2546459-002mg	MyBiosource	0.02mg	EUR 315

Recombinant Human DKK1 / Dkk-1 Protein (His tag)
MBS2546459-01mg	MyBiosource	0.1mg	EUR 605

Recombinant Human DKK1 / Dkk-1 Protein (His tag)
MBS2546459-5x01mg	MyBiosource	5x0.1mg	EUR 2715

Recombinant Human DKK1/Dkk-1 Protein (N-His)
MBS2557306-001mg	MyBiosource	0.01mg	EUR 220

Recombinant Human DKK1/Dkk-1 Protein (N-His)
MBS2557306-005mg	MyBiosource	0.05mg	EUR 505

Recombinant Human DKK1/Dkk-1 Protein (N-His)
MBS2557306-5x005mg	MyBiosource	5x0.05mg	EUR 2270

Human DKK-3 ELISA KIT
EF000091	Nova Lifetech	96tests	EUR 566

Mouse anti Human DKK1/Dkk-1 Monoclonal Antibody
MBS2543267-006mL	MyBiosource	0.06mL	EUR 250

Mouse anti Human DKK1/Dkk-1 Monoclonal Antibody
MBS2543267-012mL	MyBiosource	0.12mL	EUR 370

Mouse anti Human DKK1/Dkk-1 Monoclonal Antibody
MBS2543267-02mL	MyBiosource	0.2mL	EUR 550

Human DKK Antibody-BIOTIN
E63C02403	EnoGene	100ug/100ul	EUR 275
Description: Available in various conjugation types.

Human DKK Antibody-BIOTIN
MBS857030-01mg	MyBiosource	0.1mg	EUR 345

Human DKK Antibody-BIOTIN
MBS857030-5x01mg	MyBiosource	5x0.1mg	EUR 1410

human Dkk-3 Recombinant Protein
100-408	ReliaTech	10 µg	EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-3 Recombinant Protein
100-408S	ReliaTech	2 µg	EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein
100-436	ReliaTech	10 µg	EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein
100-436S	ReliaTech	2 µg	EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

Human Dkk-2 Recombinant Protein
200-014	ReliaTech	20 µg	EUR 136.5
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Human Dkk-2 Recombinant Protein
200-014S	ReliaTech	5 µg	EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Recombinant Human Dkk-3 Protein
RP00209	Abclonal	10 μg	EUR 97.5
Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists . Dkk-3 is a secreted monomer expressed in many normal human tissues, most strongly in heart, brain and spi Show more

Recombinant Human Dkk-3 Protein
RP00355	Abclonal	10 μg	EUR 196.8

Human Dkk-1 Protein, Fc Tag (MALS verified)
DK1-H5258	ACROBIOSYSTEMS	1mg	EUR 310.3
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway Show more
Description: Human Dkk-1, Fc Tag (DK1-H5258) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221)
OKAG00221	Aviva Systems Biology	96 Wells	EUR 715.2
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Sunlong Medical™ Human Dkk-1 ELISA Kit
EL0258Hu-48T	Sunlong	48T	EUR 398

Sunlong Medical™ Human Dkk-1 ELISA Kit
EL0258Hu-96T	Sunlong	96T	EUR 655

Human Dkk-1 Protein, His Tag, premium grade
DK1-H5221	ACROBIOSYSTEMS	1mg	EUR 139.1
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway Show more
Description: Human Dkk-1 Protein, His Tag, premium grade (DK1-H5221) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Human Dkk-1 Protein, His Tag, premium grade
DK1-H5221-100ug	ACROBIOSYSTEMS	100ug	EUR 228.9
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to g Show more
Description: Human Dkk-1 Protein, His Tag, premium grade (DK1-H5221) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Human Dkk-1 Protein, His Tag, premium grade
DK1-H5221-1mg	ACROBIOSYSTEMS	1mg	EUR 1384.3
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to g Show more
Description: Human Dkk-1 Protein, His Tag, premium grade (DK1-H5221) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Human Dkk-1 Protein, His Tag, premium grade
DK1-H5221-20ug	ACROBIOSYSTEMS	20ug	EUR 141.7
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to g Show more
Description: Human Dkk-1 Protein, His Tag, premium grade (DK1-H5221) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Human Dickkopf Related Protein 1, DKK-1 ELISA Kit
MBS1608151-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3375

Human Dickkopf Related Protein 1, DKK-1 ELISA Kit
MBS1608151-48StripWells	MyBiosource	48-Strip-Wells	EUR 290

 

 

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