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Паклитаксел подавляет миграцию клеток злокачественной глиомы

Мастерство обучения гарантирует правильное использование средств индивидуальной защиты при моделировании клинических встреч с COVID-19

Введение: Правильное использование средств индивидуальной защиты (СИЗ) ограничивает передачу серьезных инфекционных заболеваний медицинским работникам, что критически важно в эпоху коронавирусной болезни 2019 г. (COVID-19).

Однако предыдущие исследования показали, что медицинские работники часто ошибаются при применении и снятии СИЗ. Цель этого исследования состояла в том, чтобы определить, улучшают ли основанное на моделировании, освоение навыков обучения с осознанной практикой правильное использование СИЗ врачами во время имитации клинического контакта с пациентом COVID-19.

Методы:
• Это было предварительное и последующее исследование, проведенное в отделении неотложной помощи крупной академической больницы третичного уровня с 31 марта по 8 апреля 2020 года. В нем приняли участие 117 субъектов, в том числе 56 преподавателей и 61 врач-ординатор.

Перед вмешательством все участники прошли обучение по требованию учебного заведения по использованию СИЗ с помощью онлайн-видео и дополнительных материалов.

• Участники выполнили предварительную оценку навыков с использованием контрольного списка из 21 пункта, в котором указаны шаги по правильному надеванию и снятию СИЗ. Ожидается, что участники получат минимальный проходной балл (MPS) в 100%, определенный группой экспертов с использованием методик установления стандартов Mastery Angoff и Patient Safety. Участники, которые встретились с MPS на предварительном тестировании, были освобождены от образовательного вмешательства.

• Тестирование проводилось до и после личной демонстрации правильной техники надевания и снятия и 20 минут сознательной практики. Первичным результатом было изменение оценок правильного использования СИЗ после нашего образовательного вмешательства.

Вторичные результаты включали различия в показателях успеваемости между преподавателями и врачами-резидентами, а также различия в показателях работы при надевании и снятии.

Результаты. Все участники имели средний балл до тестирования 73,1% (95% доверительный интервал [ДИ], 70,9-75,3%). Результаты предварительного тестирования преподавателей и резидентов были схожими (75,1% против 71,3%, p = 0,082).

Средние баллы за снятие предметов перед тестированием были ниже, чем баллы за надевание, у всех участников (65,8% против 82,8%, p <0,001). Баллы участников увеличились на 26,9% (95% ДИ разницы 24,7-29,1%, p <0,001) после нашего образовательного вмешательства, в результате чего все участники достигли 100% MPS.

Заключение: Вмешательство в овладение мастерством с осознанной практикой обеспечило правильное использование СИЗ субъектами врачей в симулированной клинической встрече с пациентом COVID-19. Необходимо дальнейшее изучение результатов трансляции.

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human anti-human IL-4 mAb (C1)
E4A09D04-C1 50ug
EUR 255
Description: Available in various conjugation types.
Anti-Human IL-4
GWB-BIG229 500ug Ask for price
Anti-Human IL-4 Antibody
101-M05 500 µg
EUR 246.75
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Anti-Human IL-4 Antibody
101-M508 100 µg
EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Anti-Human IL-4 Antibody
102-P34 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Anti-human IL-4 antibody
STJ15100045 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.
Anti-human IL-4 antibody
STJ15100046 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.
Anti‐Human IL‐17A
E2790213 100ul
EUR 225
Description: Available in various conjugation types.
IL-4, Human
E34M006H 5 μg
EUR 155
Human IL-4
GWB-CB2917 0.01 mg Ask for price
Human IL-4
gAP-0227 1mg
EUR 450
Human Interleukin-4 (IL-4) Antibody
32184-05111 150 ug
EUR 215
anti- IL-4 antibody
FNab09861 100µg
EUR 658.5
  • Recommended dilution: WB: 1:500 - 1:1000
  • Immunogen: interleukin 4
  • Uniprot ID: P05112
  • Gene ID: 3565
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against IL-4
anti- IL-4 antibody
FNab04278 100µg
EUR 702
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:100
  • Immunogen: interleukin 4
  • Uniprot ID: P05112
  • Gene ID: 3565
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against IL-4
anti- IL-4 antibody
FNab04279 100µg
EUR 702
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: interleukin 4
  • Uniprot ID: P05112
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against IL-4
anti- IL-4 antibody
LSMab09861 100 ug
EUR 463.2
Anti-IL-4 Antibody
E38A8953 100ug/100ul
EUR 225
Description: Available in various conjugation types.
Anti-IL-4 Antibody
E38A8961 100ug/100ul
EUR 225
Description: Available in various conjugation types.
Anti-IL-4 Antibody
ER1706-55 100ul
EUR 189
  • Recombinant protein within human IL4 aa 73-459.
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNFβ and IFN-γ, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2, and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.
Anti-IL-4 antibody
PAab04278 100 ug
EUR 494.4
Anti-IL-4 antibody
STJ96510 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.
Anti-IL-4 antibody
STJ93699 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.
Anti-IL-4 antibody
STJ93700 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.
PE Anti-Human IL-4 Antibody
DL22181F-20Tests 20Tests
EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
PE Anti-Human IL-4 Antibody
DL22181F-50Tests 50Tests
EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
APC Anti-Human IL-4 Antibody
DL22182F-20Tests 20Tests
EUR 245
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
APC Anti-Human IL-4 Antibody
DL22182F-50Tests 50Tests
EUR 357.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
Rat Anti-Human IL-4, Antibody
GWB-600465 0.5 mg Ask for price
Rat Anti-Human IL-4, Antibody
GWB-ACBDBA 0.5 mg Ask for price
Rat Anti-Human IL-4, Antibody
GWB-C54D97 0.5 mg Ask for price
FITC Anti-Human IL-4 Antibody
DL22180F-20Tests 20Tests
EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
FITC Anti-Human IL-4 Antibody
DL22180F-50Tests 50Tests
EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
Purified Anti-Human IL-4 Antibody
DL22179F-100ug 100μg
EUR 290
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
Purified Anti-Human IL-4 Antibody
DL22179F-25ug 25μg
EUR 177.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
mAb mouse anti-human IL-4
CT253 0.5 mg
EUR 312
mouse anti-human IL-4 mAb
E409C13-m100 100μL
EUR 395
Description: Available in various conjugation types.
Rabbit anti-Human IL-4(CAP)
RM17744 1000μg Ask for price
Rabbit anti-Human IL-4(DET)
RM17745 100μg Ask for price
Mouse Monoclonal anti-human IL-4
hAP-0404 100ug
EUR 250
Sheep Polyclonal anti-human IL-4
hAP-5265 50ug
EUR 400
human anti-human IL-2 mAb
E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.
human anti-human IL-5 mAb
E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.
human anti-human IL-8 mAb
E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.
human anti-human IL-5 mAb
E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-1β mAb
E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.
human anti-human IL-10 mAb
E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.
human anti-human IL-12/IL-23 p40 mAb(3H2)
E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-12/IL-23 p40 mAb(5N9)
E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
Human Interleukin-4 (IL-4)
1-CSB-EP011659HU
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 31 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli
Interleukin-4 (IL-4) Human
GWB-2A39E4 0.01 mg Ask for price
  • Interleukin-4 (IL-4) Human was previously known under catalogue number 10-251-407123 was previously known under catalogue number 10-251-407123
IL-4, Interleukin-4, human
RC212-15 5ug
EUR 125.26
  • Product category: Proteins/Recombinant Proteins/Cytokines
human anti-human IL-12/IL-23 p40 mAb(1G11)
E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
Anti-Interleukin-4 (IL-4) Antibody
Y108183 50 μg
EUR 455
rec IL-4 (human)
H-9630.0002 2.0µg
EUR 313.2
rec IL-4 (human)
H-9630.0010 10.0µg
EUR 1140
Human IL-4 Protein
abx060798-20ug 20 ug
EUR 560.4
  • Shipped within 5-10 working days.
Human IL-4 protein
PRP100273-100ug 100 μg
EUR 1029
Description: Human IL-4 protein, expressed in E. coli
Human IL-4 protein
PRP100273-1mg 1 mg
EUR 7139
Description: Human IL-4 protein, expressed in E. coli
Human IL-4 protein
PRP100273-20ug 20 μg
EUR 509
Description: Human IL-4 protein, expressed in E. coli
Human IL-4 protein
PRP2017-100ug 100 μg
EUR 429
Description: Human IL-4 protein, expressed in HEK293 Cells
Human IL-4 protein
PRP2017-10ug 10 μg
EUR 59
Description: Human IL-4 protein, expressed in HEK293 Cells
Human IL-4 protein
PRP2017-1mg 1 mg
EUR 3739
Description: Human IL-4 protein, expressed in HEK293 Cells
Human IL-4 protein
PRP2017-50ug 50 μg
EUR 249
Description: Human IL-4 protein, expressed in HEK293 Cells
Recombinant Human IL-4
6486 5 µg
EUR 194
IL-4, human recombinant
4137-10 each
EUR 333.6
IL-4, human recombinant
4137-1000 each
EUR 4444.8
IL-4, human recombinant
4137-50 each
EUR 836.4
Recombinant Human IL-4
HEILP-0401 5ug Ask for price
Recombinant Human IL-4
P0052 100ug
EUR 626.83
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P05112
Description: Recombinant Human protein for IL-4
Recombinant Human IL-4
SJB02-03 10µg/vial
EUR 342
Recombinant Human IL-4
SJB02-05 100µg/vial
EUR 864
Recombinant Human IL-4
SJB02-06 30µg/vial
EUR 516
Recombinant human IL-4
rcyec-hil4 10 µg
EUR 156.45
human IL-10 / IL-4 (without plate)
M874022001 1 unit
EUR 244.37
human IL-10 / IL-4 (without plate)
M874030001 1 unit
EUR 266.67
Human IL-4 Antibody Pair Set
ABPR-ZB073 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human IL-4
Human IL-4 ELISA antibody pair
CT742-10 10-plate
EUR 656.4
Human IL-4 ELISA antibody pair
CT742-20 20-plate
EUR 1118.4
Polyclonal Anti- human IL-3 Antibody
GWB-BBP009 0.1 mg Ask for price
Polyclonal Anti- human IL-6 Antibody
GWB-BBP013 0.1 mg Ask for price
Polyclonal Anti- human IL-7 Antibody
GWB-BBP014 0.1 mg Ask for price
Anti-Rat IL-4 Antibody
104-P05 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Rat anti-IL-4 Antibody
DL99451A-100ul 100 ul
EUR 299
  • CHO-expressed recombinant human IL-4
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rat anti-IL-4 Antibody
DL99451A-50ul 50 ul
EUR 210
  • CHO-expressed recombinant human IL-4
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rat anti-IL-4 Antibody
DL99459A-100ul 100 ul
EUR 299
  • 1mg/mL
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rat anti-IL-4 Antibody
DL99459A-50ul 50 ul
EUR 210
  • 1mg/mL
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Anti-IL-4 Antibody [A7D7]
HA601034 100ul
EUR 210
  • Recombinant protein within Human aa 20-153 / 153.
Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Polyclonal Anti- human IL-10 Antibody
GWB-BBP015 0.1 mg Ask for price
Anti-Mouse IL-4 Antibody
103-M422 100 µg
EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Anti-Mouse IL-4 Antibody
103-P14 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Anti-mouse IL-4 antibody
STJ15100035 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.
Anti-mouse IL-4 antibody
STJ15100036 500 µg
EUR 632.4
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.
Anti-mouse IL-4 antibody
STJ15100037 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.
Anti-IL-4 alpha antibody
STJ97665 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.
Anti-IL-4 alpha antibody
STJ93702 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.
Anti-IL-4 alpha antibody
STJ93703 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.
Rabbit anti-IL-4 Antibody
DL90589A-100ul 100 ul
EUR 289
  • KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-4. The exact sequence is proprietary.
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rabbit anti-IL-4 Antibody
DL90589A-50ul 50 ul
EUR 202.3
  • KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-4. The exact sequence is proprietary.
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rabbit anti-IL-4 Antibody
DL90590A-100ul 100 ul
EUR 316
  • KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IL-4. The exact sequence is proprietary.
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rabbit anti-IL-4 Antibody
DL90590A-50ul 50 ul
EUR 221.2
  • KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IL-4. The exact sequence is proprietary.
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rabbit anti-IL-4 Antibody
DL90591A-100ul 100 ul
EUR 299
  • KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-4. The exact sequence is proprietary.
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rabbit anti-IL-4 Antibody
DL90591A-50ul 50 ul
EUR 209.3
  • KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-4. The exact sequence is proprietary.
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Rabbit anti-IL-4 Antibody
YLD4337-100ul 100 ul
EUR 320
  • Western blot analysis of IL-4 expression in HeLa (A), Raji (B) whole cell lysates.
Description: Rabbit polyclonal antibody to IL-4
Rabbit anti-IL-4 Antibody
YLD4337-50ul 50 ul
EUR 200
  • Western blot analysis of IL-4 expression in HeLa (A), Raji (B) whole cell lysates.
Description: Rabbit polyclonal antibody to IL-4
Rabbit anti-IL-4 Antibody
YLD4338-100ul 100 ul
EUR 320
  • Western blot analysis of IL-4 expression in Jurkat (A), human tonsil (B) whole cell lysates.
Description: Rabbit polyclonal antibody to IL-4
Rabbit anti-IL-4 Antibody
YLD4338-50ul 50 ul
EUR 200
  • Western blot analysis of IL-4 expression in Jurkat (A), human tonsil (B) whole cell lysates.
Description: Rabbit polyclonal antibody to IL-4
Rabbit anti-IL-4 Antibody
YLD4339-100ul 100 ul
EUR 320
  • Western blot analysis of IL-4 expression in MCF7 (A), SP2/0 (B), PC12 (C) whole cell lysates.
Description: Rabbit polyclonal antibody to IL-4
Rabbit anti-IL-4 Antibody
YLD4339-50ul 50 ul
EUR 200
  • Western blot analysis of IL-4 expression in MCF7 (A), SP2/0 (B), PC12 (C) whole cell lysates.
Description: Rabbit polyclonal antibody to IL-4
Polyclonal Anti- IL-4 Antibody
GWB-BBP303 0.1 mg Ask for price
APC-Cy7 anti-human IL-4 Antibody
E16FHOIL4-025 25 tests
EUR 630
Description: Available in various conjugation types.
APC-Cy7 anti-human IL-4 Antibody
E16FHOIL4-100 100 tests
EUR 1365
Description: Available in various conjugation types.
Human IL-4 ELISPOT antibody pair
CT642-10 10-plate
EUR 633.6
Human IL-4 ELISPOT antibody pair
CT642-20 20-plate
EUR 1107.6
Polyclonal Anti-IL-4 Antibody
GWB-BBP406 0.1 mg Ask for price
Polyclonal Anti-IL-4 Antibody
GWB-BBP624 0.1 mg Ask for price
Rat Monoclonal anti-Human IL-4 Antibody
xAP-0428 100ug
EUR 280
Mouse Monoclonal anti-Human IL-4 Antibody
xAP-0429 100ug
EUR 280
Anti-Human IL-4 Rabbit Polyclonal Antibody
TA328211 100 µg Ask for price
human anti-human IL-2 mAb (D1)
E4A09D03-A7C 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-2 mAb (F5)
E4A09D03-B1F 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-2 mAb (16)
E4A09D03-C3C 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-6 mAb (A3)
E4A09D06-hA3 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-8 mAb (A5)
E4A09D07-A5A 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-8 mAb (6G)
E4A09D07-B5G 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-8 mAb (AB)
E4A09D07-C8A 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-8 mAb(N2)
E4A09D07-N2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-8 mAb(N8)
E4A09D07-N8 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-1β mAb (95)
E4A09D02-h9 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-1β mAb (Ca)
E4A09D02-hA 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-1β mAb (Ge)
E4A09D02-hB 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-6 mAb (10C)
E4A09D06-h10C 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-6 mAb (2D2)
E4A09D06-hD2 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-10 mAb (97)
E4A09D08-A9D 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-10 mAb (18)
E4A09D08-B2G 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-15 mAb(1A)
E4A09D21-1A 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-15 mAb(2B)
E4A09D21-2B 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-15 mAb(7C)
E4A09D21-7C 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-15 mAb(9E)
E4A09D21-9E 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-13 mAb(11)
E4A09D31-11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-13 mAb(18)
E4A09D31-18 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-13 mAb(21)
E4A09D31-21 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-13 mAb(28)
E4A09D31-28 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-33 mAb(6N)
E4A09D36-6N 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-33 mAb(7B)
E4A09D36-7B 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-33 mAb(8N)
E4A09D36-8N 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-33 mAb(A4)
E4A09D36-A4 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-33 mAb(E1)
E4A09D36-E1 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
mouse anti-human IL-4 mAb(08)
E4A09D04-m-08 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
mouse anti-human IL-4 mAb(10)
E4A09D04-m-10 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human DIAplex Human Th2 Complete - IL-4, IL-6,
M880120003 1 unit
EUR 515.63
human anti-human IL-6 mAb (3H3H)
E4A09D06-h3H 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-6 mAb (1H4C)
E4A09D06-h4C 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-6 mAb (2H4Z)
E4A09D06-h4Z 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-6 mAb (4HC6)
E4A09D06-hC6 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-12 mAb (AB1)
E4A09D20-AB1 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-12 mAb (AB2)
E4A09D20-AB2 50ug
EUR 255
Description: Available in various conjugation types.
human anti-human IL-23 mAb(2C2)
E4A09D32-2C2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-23 mAb(7D3)
E4A09D32-7D3 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-22 mAb(1F4)
E4A09D35-1F4 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
human anti-human IL-22 mAb(3A1)
E4A09D35-3A1 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Размышления врачей-интернов об их обучении использованию средств индивидуальной защиты

История вопроса: Текущая пандемия COVID-19 продемонстрировала, что средства индивидуальной защиты (СИЗ) необходимы для предотвращения заражения и передачи инфекционных заболеваний, однако их использование в клинических условиях часто не оптимально.

Обучение и образование важны для обеспечения и поддержания безопасного и эффективного использования СИЗ медицинскими интернами, но существующие методы часто неадекватны для обеспечения соответствующих знаний и навыков.

Целью этого исследования было изучить опыт выпускников медицинских вузов по использованию СИЗ и выявить возможности для улучшения образовательных и учебных программ с целью повышения профессиональной безопасности и безопасности пациентов.

Методы: это исследование было проведено в 2018 году в крупной клинической больнице третичного уровня в Сиднее, Австралия, для изучения собственного опыта использования СИЗ медицинскими стажерами в начале их стажировки.

Рефлексивные группы были собраны сразу после теоретического и практического обучения СИЗ, во время ориентации в больнице. Стенограммы записанных дискуссий были проанализированы с использованием тематического подхода, основанного на модели поведения COM-B (способность, возможность, мотивация – поведение).

Результаты: приняли участие 80% из 90 подходящих выпускников. Многие стажеры ранее не получали формального обучения специальным навыкам, необходимым для оптимального использования СИЗ, и выработали потенциально небезопасные привычки.

Их опыт студентов-медиков в клинических областях резко контрастировал с рекомендуемой практикой, преподаваемой в больницах, и повлиял на их способность культивировать правильное использование СИЗ.

Выводы: обучение в бакалавриате должно соответствовать передовой практике использования СИЗ и включать практическое обучение, включающее правильные и безопасные методы.

Прогностическая ценность сверхэкспрессии ферментов, связанных с метаболизмом жирных кислот, при плоскоклеточном раке головы и шеи

Перепрограммирование метаболизма подвижных жизненных сил, соответствующего метаболизму липидов, является индикатором плоскоклеточного рака вершины и шеи (SCCHN). Тем не менее, остается неясным, влияет ли экспрессия белка, связанная с окислением жирных кислот (FAO) на выживаемость в SCCHN.

Мы стремились проанализировать экспрессию ферментов, связанных с ФАО, и определить ее корреляцию с клинико-патологическими переменными у пациентов с SCCHN. Иммуногистохимическая оценка (ИГХ) экспрессии белка, связанного с ФАО, вместе с карнитин-пальмитоилтрансферазой 1 (СРТ1), ацил-КоА-дегидрогеназой и синтазой жирных кислот (FAS) была проведена с использованием тканевых микрочипов из 102 резецированных опухолей SCCHN.

Выражения были классифицированы в соответствии с оценками IHC, и была решена статистическая принадлежность к клинико-патологическим компонентам. Относительно высокой экспрессии длинноцепочечной ацил-КоА-дегидрогеназы (LCAD) была защитная функция от смерти, связанной с раком (скорректированное отношение рисков (HR), 0,2; 95% доверительный интервал (CI), 0,05-0,87) после ковариации корректирование.

Возраст и медицинская стадия оставались объективными предикторами выживаемости (скорректированный HR, 1,75; 95% ДИ, 1,22–2,49 для возраста; скорректированный HR, 14,33; 95% ДИ, 1,89-108,60 для стадии III / IV).
Сверхэкспрессия ацил-CoA дегидрогеназы со средней длиной цепи и FAS коррелировала с высшей стадией опухоли (T3 / T4); тем не менее, ни один из этих компонентов не был объективным предиктором выживаемости.

Было повышено количество ферментов, связанных с ФАО, и сверхэкспрессия LCAD оказала защитное влияние на общую выживаемость у пациентов с более сильным SCCHN. Экспрессия ферментов, связанных с ФАО, может потребовать прогноза по результатам выживаемости при SCCHN.

 

Паклитаксел подавляет миграцию клеток злокачественной глиомы CD133 + U251 за счет снижения экспрессии гликолитических ферментов.

• Жизнеспособное метаболическое перепрограммирование (EMR) позволяет перестраивать последовательность метаболических генов и белков, когда опухолевые клетки адаптируются к своему микроокружению.

EMR характеризуется модификациями метаболического образца и промежуточных продуктов метаболизма, чтобы удовлетворить потребности опухолевых клеток в его или ее злокачественном разрастании и инфильтративном прогрессе.

• В текущем исследовании изучалась функция паклитаксела в низких дозах (PTX) в изменении диапазонов экспрессии ключевых генов и белков в процессе гликолиза в клетках глиомы CD133 + U251 и изучались связанные механизмы регуляции движения на молекулярном уровне.

Иммуномагнитные шарики CD133 были использованы для злокачественных клеток глиомы CD133 + U251, которые затем были разделены прямо на группу, подвергшуюся вредному лечению, и экспериментальную группу, обработанную 1, 2, 4 или 8 мкМ PTX в течение 72 часов.

• Пакет для подсчета клеток-8 (CCK-8) использовался для измерения пролиферации клеток U251. РНК и белок были извлечены из клеток злокачественной глиомы во всех группах, чтобы наблюдать за изменениями в диапазонах экспрессии ключевых гликолитических ферментов, соответствующих переносчику глюкозы 1 (GLUT1), пируваткиназе M (PKM) и лактатдегидрогеназе A (LDHA), используя количественная ПЦР с обратной транскрипцией и вестерн-блоттинг.

Для количественной оценки результатов разрешения РТХ на клетках U251 были проведены анализы миграции через лунки. Клетки глиомы CD133 + U251 удалялись эффективно.

• Клетки CD1133 + имели лучшую цену пролиферации по сравнению с клетками CD1133-. В клетках CD1133 +, обработанных PTX, дозозависимая скидка в пределах диапазонов экспрессии важных гликолитических ферментов GLUT1, PKM и LDHA была замечена в каждом диапазоне мРНК и белка.

Разрешение PTX дополнительно ингибировало миграцию клеток. Различия между управляющими и экспериментальными группами были статистически значимыми (P <0,05).

• Поскольку гликолиз выполняет незаменимую функцию в пролиферации и миграции клеток глиомы, подобных стволовым, PTX может ингибировать прогрессирование опухолевых клеток путем подавления диапазонов экспрессии генов и белков гликолитических ферментов в клетках глиомы CD133 +.

 

Human DKK-1 ELISA Kit

EK5390 96 tests
EUR 599
  • https://www.sabbiotech.com/g-138088-Human-DKK-1-ELISA-Kit-EK5390.html

Human Dkk-1 ELISA Kit

GWB-SKR221 96 Tests Ask for price

Human DKK-1 ELISA kit

LF-EK50797 1×96T
EUR 777.6

Human CellExp? DKK-1, Human Recombinant

7132-10 each
EUR 333.6

Human CellExp? DKK-1, Human Recombinant

7132-50 each
EUR 1358.4

DKK-1 (HEK293-expressed), Human

HY-P7155A 50ug
EUR 1011.6

human Dkk-1 Recombinant Protein

100-407 10 µg
EUR 196.35
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

human Dkk-1 Recombinant Protein

100-407S 2 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013 20 µg
EUR 136.5
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013S 5 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Recombinant Human DKK-1 Protein

PROTO94907-3 10ug
EUR 380.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1

GT30000 50 ug
EUR 631.2

Human DKK Antibody

E63C02401 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Human DKK-1 PicoKine ELISA Kit

EK0867 96 wells
EUR 510
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Active Recombinant Human Dkk-1 Protein

RP01343 100μg
EUR 162.5
  • Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway
  • Show more

Human DKK-1 Recombinant Protein Lyophilized

IHUDKK1RLY2UG each
EUR 341
  • Wet Ice
Description: Human DKK-1 Recombinant Protein Lyophilized

Human DKK-1 ELISA kit (4×96T)

LF-EK50798 4×96T
EUR 2641.2

Nori® Human DKK-1 ELISA Kit

GR106268 96-well
EUR 461

DKK-1 Antibody

F51803-0.4ML 0.4 ml
EUR 322.15
  • In 1X PBS, pH 7.4, with 0.09% sodium azide
Description: DKK-1 is a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

OKAG00221-96W - Dkk-1 ELISA Kit (Human)

OKAG00221-96W 1plate:12x8-WellMicrostrips
EUR 475
  • Dkk-1 ELISA Kit (Human)

OKRC00363-96W - Dkk-1 ELISA Kit (Human)

OKRC00363-96W 96Wells
EUR 525
  • Dkk-1 ELISA Kit (Human)

Human DKK Antibody-HRP

E63C02402 100ug/100ul
EUR 275
Description: Available in various conjugation types.

DKK-3 ELISA KIT|Human

EF000091 96 Tests
EUR 826.8

Human DKK Antibody-BIOTIN

E63C02403 100ug/100ul
EUR 275
Description: Available in various conjugation types.

Recombinant Human DKK1/Dkk-1 Protein (His Tag)

PKSH033697-10ug 10ug
EUR 178
  • > 95 % as determined by reducing SDS-PAGE.
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)

PKSH033697-50ug 50ug
EUR 523
  • > 95 % as determined by reducing SDS-PAGE.
Description: Human

human Dkk-3 Recombinant Protein

100-408 10 µg
EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-3 Recombinant Protein

100-408S 2 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein

100-436 10 µg
EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein

100-436S 2 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

Human Dkk-2 Recombinant Protein

200-014 20 µg
EUR 136.5
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Human Dkk-2 Recombinant Protein

200-014S 5 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Recombinant Human Dkk-3 Protein

RP00209 10 μg
EUR 97.5
  • Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists . Dkk-3 is a secreted monomer expressed in many normal human tissues, most strongly in heart, brain and spi
  • Show more

Recombinant Human Dkk-3 Protein

RP00355 10 μg
EUR 196.8

Anti-Human Dkk-1 Antibody

101-M380 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Anti-Human Dkk-1 Antibody

101-M426 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Anti-Human Dkk-1 Antibody

102-PA33 200 µg
EUR 204.75
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Anti-Human Dkk-1 Antibody

102-PA33S 100 µg
EUR 126
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Protein, Fc Tag (MALS verified)

DK1-H5258 1mg
EUR 310.3
  • Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway
  • Show more
Description: Human Dkk-1, Fc Tag (DK1-H5258) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221)

OKAG00221 96 Wells
EUR 715.2
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Human Dkk-1 Protein, His Tag, premium grade

DK1-H5221 1mg
EUR 139.1
  • Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway
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Description: Human Dkk-1 Protein, His Tag, premium grade (DK1-H5221) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Biotinylated Human Dkk-1 Protein, Fc,Avitag™

DK1-H82F5 25ug
EUR 1487.3
  • Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway
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Description: Biotinylated Human Dkk-1, Fc,Avitag (DK1-H82F5) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # O94907-1).

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EH0113 96T
EUR 628.92
  • Detection range: 31.25-2000 pg/ml
  • Uniprot ID: O94907
  • Alias: DKK1/dickkopf(Xenopus laevis) homolog 1/dickkopf homolog 1(Xenopus laevis)/dickkopf related protein-1/Dickkopf-1/dickkopf-related protein 1/Dkk-1/DKK-1/SKdickkopf-1 like
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-48T 48T
EUR 396.9

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-5x96T 5x96T
EUR 2693.25

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-96T 96T
EUR 567

Rabbit Anti Human DKK PcAb

E61C02403 100ug
EUR 225
Description: Available in various conjugation types.

Rabbit Anti Human DKK PcAb

E61C02403a 1mg
EUR 1125
Description: Available in various conjugation types.

Dkk-1 Rabbit pAb

E2251891 100ul
EUR 225
Description: Available in various conjugation types.

Recombinant Human DKK-1/DKK1 Protein, 8* His Tag

E40KMH986 20ug
EUR 495

Human DKK-2 Protein, His Tag

DK2-H5323 1mg
EUR 224.7
  • This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in res
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Description: Human DKK-2 Protein, His Tag (DK2-H5323) is expressed from CHO cells. It contains AA Lys 34 - Ile 259 (Accession # Q9UBU2).

Recombinant Human DKK1/Dkk-1 Protein (His Tag)(Active)

PKSH031807-100ug 100ug
EUR 636
  • > 90 % as determined by reducing SDS-PAGE.
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)(Active)

PKSH031807-20ug 20ug
EUR 303
  • > 90 % as determined by reducing SDS-PAGE.
Description: Human

Human DKK-3 PicoKine ELISA Kit

EK1323 96 wells
EUR 510
Description: For quantitative detection of human DKK-3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human DKK-4 PicoKine ELISA Kit

EK0868 96 wells
EUR 546
Description: For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA).

Dkk-1 Recombinant Protein

96-861 0.1 mg
EUR 651.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Recombinant Protein

96-990 0.05 mg
EUR 714.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Polyclonal Antibody

ABP53293-003ml 0.03ml
EUR 189.6
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human Dkk-1
  • Applications tips:
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-01ml 0.1ml
EUR 346.8
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human Dkk-1
  • Applications tips:
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-02ml 0.2ml
EUR 496.8
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human Dkk-1
  • Applications tips:
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

41928-100ul 100ul
EUR 302.4

Dkk-1 Polyclonal Antibody

41928-50ul 50ul
EUR 224.4

DKK-1 Recombinant Protein

40-225-0002mg 0.002 mg
EUR 311.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 Recombinant Protein

40-225-001mg 0.01 mg
EUR 437.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1 Polyclonal Antibody

E041928 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Dkk-1 Polyclonal Antibody

E20-75562 100ug
EUR 225
Description: Available in various conjugation types.

Dkk-1 Polyclonal Antibody

E44H07004 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

DKK-3 ELISA Kit (Human) (OKBB00603)

OKBB00603 96 Wells
EUR 606
Description: Description of target: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Nori® Human DKK-1 ELISA Kit (2 plates)

GR106268-2 2 x 96-well
EUR 832

Dkk-2

GT15222 100 ug
EUR 631.2

Human DKK-2 Recombinant Protein Lyophilized

IHUDKK2RLY2UG each
EUR 317
  • Wet Ice
Description: Human DKK-2 Recombinant Protein Lyophilized

Human DKK-3 Recombinant Protein Lyophilized

IHUDKK3RLY2UG each
EUR 317
  • Wet Ice
Description: Human DKK-3 Recombinant Protein Lyophilized

Mouse Monoclonal anti-human Dkk-1

hAP-0246 100ug
EUR 250

Mouse Monoclonal anti-human Dkk-1

hAP-0246A 100ug
EUR 250

Sheep Polyclonal anti-Human Dkk-1

hAP-5846 50ug
EUR 400

Biotinylated Recombinant Human Dkk-3 Protein

RP02554 100μg
EUR 1423.5
  • Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists.DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes s
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Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-10ug 10ug
EUR 100
  • > 95 % as determined by reducing SDS-PAGE.
Description: Human

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-50ug 50ug
EUR 300
  • > 95 % as determined by reducing SDS-PAGE.
Description: Human

Human Dkk-3 (R335G) Protein, His Tag

DK3-H5220 20ug
EUR 460.1
  • Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3
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Description: Human Dkk-3 (R335G), His Tag (DK3-H5220) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).

DKK 1 Recombinant Protein

96-236 0.1 mg
EUR 752.1
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

DKK 1 Recombinant Protein

96-237 0.025 mg
EUR 619.8
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Rat DKK-1 ELISA Kit

EK5668 96 tests
EUR 599
  • https://www.sabbiotech.com/g-138366-Rat-DKK-1-ELISA-Kit-EK5668.html

Mouse Dkk-1 ELISA KIT

E42EM-173 96T/48T Ask for price

Mouse Dkk-1 ELISA Kit

E28L0661 96T
EUR 666.67

OKBB00603-96W - DKK-3 ELISA Kit (Human)

OKBB00603-96W 96Wells
EUR 538
  • DKK-3 ELISA Kit (Human)

OKRC00364-96W - Dkk-3 ELISA Kit (Human)

OKRC00364-96W 96Wells
EUR 525
  • Dkk-3 ELISA Kit (Human)

OKRC00365-96W - Dkk-4 ELISA Kit (Human)

OKRC00365-96W 96Wells
EUR 525
  • Dkk-4 ELISA Kit (Human)

DKK-1 (CHO-expressed), Mouse

HY-P7154 50ug
EUR 914.4

Dkk-1 Rabbit Polyclonal Antibody

ES4292-100ul 100ul
EUR 124
  • WB, IHC, ELISA
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Dkk-1 Rabbit Polyclonal Antibody

ES4292-50ul 50ul
EUR 74
  • WB, IHC, ELISA
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

 

 

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