Мастерство обучения гарантирует правильное использование средств индивидуальной защиты при моделировании клинических встреч с COVID-19

Введение: Правильное использование средств индивидуальной защиты (СИЗ) ограничивает передачу серьезных инфекционных заболеваний медицинским работникам, что критически важно в эпоху коронавирусной болезни 2019 г. (COVID-19).

Однако предыдущие исследования показали, что медицинские работники часто ошибаются при применении и снятии СИЗ. Цель этого исследования состояла в том, чтобы определить, улучшают ли основанное на моделировании, освоение навыков обучения с осознанной практикой правильное использование СИЗ врачами во время имитации клинического контакта с пациентом COVID-19.

Методы:
• Это было предварительное и последующее исследование, проведенное в отделении неотложной помощи крупной академической больницы третичного уровня с 31 марта по 8 апреля 2020 года. В нем приняли участие 117 субъектов, в том числе 56 преподавателей и 61 врач-ординатор.

Перед вмешательством все участники прошли обучение по требованию учебного заведения по использованию СИЗ с помощью онлайн-видео и дополнительных материалов.

• Участники выполнили предварительную оценку навыков с использованием контрольного списка из 21 пункта, в котором указаны шаги по правильному надеванию и снятию СИЗ. Ожидается, что участники получат минимальный проходной балл (MPS) в 100%, определенный группой экспертов с использованием методик установления стандартов Mastery Angoff и Patient Safety. Участники, которые встретились с MPS на предварительном тестировании, были освобождены от образовательного вмешательства.

• Тестирование проводилось до и после личной демонстрации правильной техники надевания и снятия и 20 минут сознательной практики. Первичным результатом было изменение оценок правильного использования СИЗ после нашего образовательного вмешательства.

Вторичные результаты включали различия в показателях успеваемости между преподавателями и врачами-резидентами, а также различия в показателях работы при надевании и снятии.

Результаты. Все участники имели средний балл до тестирования 73,1% (95% доверительный интервал [ДИ], 70,9-75,3%). Результаты предварительного тестирования преподавателей и резидентов были схожими (75,1% против 71,3%, p = 0,082).

Средние баллы за снятие предметов перед тестированием были ниже, чем баллы за надевание, у всех участников (65,8% против 82,8%, p <0,001). Баллы участников увеличились на 26,9% (95% ДИ разницы 24,7-29,1%, p <0,001) после нашего образовательного вмешательства, в результате чего все участники достигли 100% MPS.

Заключение: Вмешательство в овладение мастерством с осознанной практикой обеспечило правильное использование СИЗ субъектами врачей в симулированной клинической встрече с пациентом COVID-19. Необходимо дальнейшее изучение результатов трансляции.

Human anti-Human IL-4 mAb
MBS8576802-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-4 mAb
MBS8576802-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Polyclonal Anti- human IL-4 Antibody
GWB-BBP010	GenWay Biotech	0.1 mg	Ask for price

human anti-human IL-4 mAb(12)
E4A09D04-12	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb(52)
E4A09D04-52	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb(C1)
E4A09D04-C1	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

Human anti-human IL-4 mAb (C1)
A09D04-C1	BioNC	1 Each	Ask for price

Human anti-human IL-4 mAb (D44)
A09D04-D44	BioNC	1 Each	Ask for price

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396740-01mg	MyBiosource	0.1mg	EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396740-5x01mg	MyBiosource	5x0.1mg	EUR 1015

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396742-01mg	MyBiosource	0.1mg	EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396742-5x01mg	MyBiosource	5x0.1mg	EUR 1015

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396744-01mg	MyBiosource	0.1mg	EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated
MBS396744-5x01mg	MyBiosource	5x0.1mg	EUR 1015

Anti-Human IL-4
GWB-BIG229	GenWay Biotech	500ug	Ask for price

Anti-Human IL-4
MBS550674-01mg	MyBiosource	0.1mg	EUR 260

Anti-Human IL-4
MBS550674-02mg	MyBiosource	0.2mg	EUR 335

Anti-Human IL-4
MBS550686-01mg	MyBiosource	0.1mg	EUR 260

Anti-Human IL-4
MBS550686-02mg	MyBiosource	0.2mg	EUR 335

Anti-Human IL-4
RH400020	Antigenix America	100 µg	Ask for price

Anti-Human IL-4
MC444020	Antigenix America	0.5 mg	Ask for price

Anti‐Human IL‐17A
E2790213	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Human IL-4
GWB-CB2917	GenWay Biotech	0.01 mg	Ask for price

Human IL-4
gAP-0227	Angio Proteomie	1mg	EUR 450

IL-4， Human
E34M006H	EnoGene	5 μg	EUR 155

Human IL-4
MBS691496-0002mg	MyBiosource	0.002mg	EUR 225

Human IL-4
MBS691496-5x0002mg	MyBiosource	5x0.002mg	EUR 725

Human IL-4
MBS691811-005mg	MyBiosource	0.05mg	EUR 555

Human IL-4
MBS691811-5x005mg	MyBiosource	5x0.05mg	EUR 2205

Human IL-4
MBS691915-001mg	MyBiosource	0.01mg	EUR 265

Human IL-4
MBS691915-5x001mg	MyBiosource	5x0.01mg	EUR 890

IL-4, Human
MBS8575163-0005mg	MyBiosource	0.005mg	EUR 245

IL-4, Human
MBS8575163-5x0005mg	MyBiosource	5x0.005mg	EUR 940

Human IL-4
HC40020	Antigenix America	20 µg	Ask for price

Human IL-4
300-154P-100ug	GeminiBio	100 µg	Ask for price

Human IL-4
300-154P-1mg	GeminiBio	1 mg	Ask for price

Human IL-4
300-154P-20ug	GeminiBio	20 µg	Ask for price

Human IL-4
300-154P-500ug	GeminiBio	500 µg	Ask for price

Human IL-4
300-154P-5ug	GeminiBio	5 µg	Ask for price

Human Interleukin-4 (IL-4) Antibody
32184-05111	AssayPro	150 ug	EUR 215

Anti-Human IL-4 Antibody
101-M05	ReliaTech	500 µg	EUR 246.75
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody
101-M508	ReliaTech	100 µg	EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody
102-P34	ReliaTech	100 µg	EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-human IL-4 antibody
STJ15100045	St John's Laboratory	250 µg	EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti-human IL-4 antibody
STJ15100046	St John's Laboratory	250 µg	EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti-Human IL-4 PE
MBS697227-100Tests	MyBiosource	100Tests	EUR 360

Anti-Human IL-4 PE
MBS697227-25Tests	MyBiosource	25Tests	EUR 215

Anti-Human IL-4 PE
MBS697227-5x100Tests	MyBiosource	5x100Tests	EUR 1580

Anti-Human IL-4 PE
MBS697234-100Tests	MyBiosource	100Tests	EUR 335

Anti-Human IL-4 PE
MBS697234-25Tests	MyBiosource	25Tests	EUR 185

Anti-Human IL-4 PE
MBS697234-5x100Tests	MyBiosource	5x100Tests	EUR 1475

PE anti-human IL-4
GT18087	Sony	25 Tests	Ask for price
Applications: Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

PE anti-human IL-4
GT18088	Sony	50 µg	Ask for price
Applications: Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

Anti-Human IL-4 APC
MBS697235-100Tests	MyBiosource	100Tests	EUR 320

Anti-Human IL-4 APC
MBS697235-25Tests	MyBiosource	25Tests	EUR 185

Anti-Human IL-4 APC
MBS697235-5x100Tests	MyBiosource	5x100Tests	EUR 1395

APC anti-human IL-4
GT18090	Sony	100 Tests	Ask for price
Applications: Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

APC anti-human IL-4
GT18089	Sony	25 Tests	Ask for price
Applications: Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

FITC anti-human IL-4
GT18085	Sony	100 Tests	Ask for price
Applications: Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

FITC anti-human IL-4
GT18086	Sony	50 µg	Ask for price
Applications: Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

Mouse Anti-Human IL-4
MBS690917-05mg	MyBiosource	0.5mg	EUR 525

Mouse Anti-Human IL-4
MBS690917-5x05mg	MyBiosource	5x0.5mg	EUR 2080

Biotin anti-human IL-4
GT18083	Sony	50 µg	Ask for price
Applications: ELISA Detection, ELISPOT Detection, Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

Biotin anti-human IL-4
GT18084	Sony	500 µg	Ask for price
Applications: ELISA Detection, ELISPOT Detection, Intracellular Staining for Flow Cytometry Reactivity: Human, Cross-Reactivity: Swine (Pig, Porcine), Rhesus

Anti-Human IL-4 - Biotin
RH400020B	Antigenix America	50 µg	Ask for price

Human Interleukin-4 (IL-4)
1-CSB-EP011659HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100ug 200ug 500ug 1MG
MW: 31 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

Interleukin-4 (IL-4) Human
GWB-2A39E4	GenWay Biotech	0.01 mg	Ask for price
Interleukin-4 (IL-4) Human was previously known under catalogue number 10-251-407123 was previously known under catalogue number 10-251-407123

IL-4, Interleukin-4, human
RC212-15	Bio Basic	5ug	EUR 125.26
Product category: Proteins/Recombinant Proteins/Cytokines

Interleukin-4 (IL-4), Human
SR106-0020	GeneDireX	20 µg	Ask for price

Interleukin-4 (IL-4), Human
SR106-0100	GeneDireX	100 µg	Ask for price

human anti-human IL-2 mAb
E409C12-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb
E409C14-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb
E409C16-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb
E4A09D05	EnoGene	50ug	EUR 255
Description: Available in various conjugation types.

Human anti-Human IL-2 mAb
MBS8576800-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-2 mAb
MBS8576800-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-2 mAb
MBS8576800-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-5 mAb
MBS8576804-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-5 mAb
MBS8576804-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-8 mAb
MBS8576808-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-8 mAb
MBS8576808-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

human anti-human IL-1β mAb
E409C11-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb
E409C17-h100	EnoGene	100μL	EUR 395
Description: Available in various conjugation types.

Human anti-Human IL-10 mAb
MBS8576810-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-10 mAb
MBS8576810-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-10 mAb
MBS8576810-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

human anti-human IL-17A mAb
E409C18-h100	EnoGene	100μL	EUR 276.5
Description: Inflammation Storm Antibodies

Human anti-Human IL-1beta mAb
MBS8576798-005mg	MyBiosource	0.05mg	EUR 325

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Human anti-Human IL-1beta mAb
MBS8576798-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Human IL-4 (AF)
300-814P-100ug	GeminiBio	100 µg	Ask for price

Human IL-4 (AF)
300-814P-1mg	GeminiBio	1 mg	Ask for price

Human IL-4 (AF)
300-814P-20ug	GeminiBio	20 µg	Ask for price

Human IL-4 (AF)
300-814P-500ug	GeminiBio	500 µg	Ask for price

Human IL-4 (AF)
300-814P-5ug	GeminiBio	5 µg	Ask for price

rec IL-4 (human)
H-9630.0002	Bachem	2.0µg	EUR 313.2

rec IL-4 (human)
H-9630.0010	Bachem	10.0µg	EUR 1140

GMP Human IL-4
300-987P-050	GeminiBio	50 µg	Ask for price

GMP Human IL-4
300-987P-100	GeminiBio	100 µg	Ask for price

GMP Human IL-4
300-987P-1mg	GeminiBio	1 mg	Ask for price

human anti-human IL-12/IL-23 p40 mAb(3H2)
E4A09D33-3H2	EnoGene	50ug	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)
E4A09D33-5N9	EnoGene	50ug	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human anti-human IL-12/IL-23 p40 mAb (3H2)
A09D33-3H2	BioNC	1 Each	Ask for price

Human anti-human IL-12/IL-23 p40 mAb (5N9)
A09D33-5N9	BioNC	1 Each	Ask for price

IL 4 Human, Yeast
PT-A02945	Novatein Biosciences, Inc.	Ask for price Ask for price Ask for price	2 µg 10 µg 1 mg

human anti-human IL-12/IL-23 p40 mAb(1G11)
E4A09D33-1G11	EnoGene	50ug	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human anti-human IL-12/IL-23 p40 mAb (1G11)
A09D33-1G11	BioNC	1 Each	Ask for price

Human IL-4 Protein
abx060798-20ug	Abbexa	20 ug	EUR 560.4
Shipped within 5-10 working days.

Human IL-4 Protein
E2PD201006	EnoGene	20ug	EUR 595

Human IL-4 Protein
MBS9718706-0005mg	MyBiosource	0.005mg	EUR 135

Human IL-4 Protein
MBS9718706-002mg	MyBiosource	0.02mg	EUR 285

Human IL-4 Protein
MBS9718706-01mg	MyBiosource	0.1mg	EUR 720

Human IL-4 Protein
MBS9718706-1mg	MyBiosource	1mg	EUR 3925

Human IL-4 Protein
MBS9718706-5x1mg	MyBiosource	5x1mg	EUR 17610

Human IL-4 protein
MBS9719248-001mg	MyBiosource	0.01mg	EUR 115

Human IL-4 protein
MBS9719248-005mg	MyBiosource	0.05mg	EUR 225

Human IL-4 protein
MBS9719248-01mg	MyBiosource	0.1mg	EUR 325

Human IL-4 protein
MBS9719248-1mg	MyBiosource	1mg	EUR 2485

Human IL-4 protein
MBS9719248-5x1mg	MyBiosource	5x1mg	EUR 11130

Human IL-4 protein
PRP100273-100ug	Abbkine	100 μg	EUR 1029
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein
PRP100273-1mg	Abbkine	1 mg	EUR 7139
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein
PRP100273-20ug	Abbkine	20 μg	EUR 509
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein
PRP2017-100ug	Abbkine	100 μg	EUR 429
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein
PRP2017-10ug	Abbkine	10 μg	EUR 59
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein
PRP2017-1mg	Abbkine	1 mg	EUR 3739
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein
PRP2017-50ug	Abbkine	50 μg	EUR 249
Description: Human IL-4 protein, expressed in HEK293 Cells

IL-4 Protein, Human
UA040026	Starter Biotechnology Co Ltd	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 µg 10 µg 50 µg 100 µg 500 µg 1 mg

IL-4, human recombinant
4137-10	Biovision	each	EUR 333.6

IL-4, human recombinant
4137-1000	Biovision	each	EUR 4444.8

IL-4, human recombinant
4137-50	Biovision	each	EUR 836.4

Recombinant Human IL-4
6486	Immunochemistry	5 µg	EUR 194

Recombinant Human IL-4
HEILP-0401	Cyagen	5ug	Ask for price

Human IL-4, Recombinant
MBS319039-002mg	MyBiosource	0.02mg	EUR 330

Human IL-4, Recombinant
MBS319039-5x002mg	MyBiosource	5x0.02mg	EUR 1385

Recombinant Human IL-4
MBS258217-0005mg	MyBiosource	0.005mg	EUR 305

Recombinant Human IL-4
MBS258217-5x0005mg	MyBiosource	5x0.005mg	EUR 1210

Recombinant Human IL-4
MBS7609188-005mg	MyBiosource	0.05mg	EUR 345

Recombinant Human IL-4
MBS7609188-02mg	MyBiosource	0.2mg	EUR 635

Recombinant Human IL-4
MBS7609188-1mg	MyBiosource	1mg	EUR 1800

Recombinant Human IL-4
MBS7609188-5x1mg	MyBiosource	5x1mg	EUR 6955

Recombinant Human IL-4
MBS7614313-005mg	MyBiosource	0.05mg	EUR 345

Recombinant Human IL-4
MBS7614313-02mg	MyBiosource	0.2mg	EUR 635

Recombinant Human IL-4
MBS7614313-1mg	MyBiosource	1mg	EUR 1800

Recombinant Human IL-4
MBS7614313-5x1mg	MyBiosource	5x1mg	EUR 6955

Recombinant Human IL-4
PH2006-.01	ApexBio	10ug	EUR 224
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human IL-4
PH2006-.1	ApexBio	10X10ug	EUR 684.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human IL-4
P1121-.005	ApexBio	5ug	EUR 108.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human IL-4
P1121-.1	ApexBio	100ug	EUR 976
Description: Peptides & Proteins|Recombinant Proteins

Размышления врачей-интернов об их обучении использованию средств индивидуальной защиты

История вопроса: Текущая пандемия COVID-19 продемонстрировала, что средства индивидуальной защиты (СИЗ) необходимы для предотвращения заражения и передачи инфекционных заболеваний, однако их использование в клинических условиях часто не оптимально.

Обучение и образование важны для обеспечения и поддержания безопасного и эффективного использования СИЗ медицинскими интернами, но существующие методы часто неадекватны для обеспечения соответствующих знаний и навыков.

Целью этого исследования было изучить опыт выпускников медицинских вузов по использованию СИЗ и выявить возможности для улучшения образовательных и учебных программ с целью повышения профессиональной безопасности и безопасности пациентов.

Методы: это исследование было проведено в 2018 году в крупной клинической больнице третичного уровня в Сиднее, Австралия, для изучения собственного опыта использования СИЗ медицинскими стажерами в начале их стажировки.

Рефлексивные группы были собраны сразу после теоретического и практического обучения СИЗ, во время ориентации в больнице. Стенограммы записанных дискуссий были проанализированы с использованием тематического подхода, основанного на модели поведения COM-B (способность, возможность, мотивация – поведение).

Результаты: приняли участие 80% из 90 подходящих выпускников. Многие стажеры ранее не получали формального обучения специальным навыкам, необходимым для оптимального использования СИЗ, и выработали потенциально небезопасные привычки.

Их опыт студентов-медиков в клинических областях резко контрастировал с рекомендуемой практикой, преподаваемой в больницах, и повлиял на их способность культивировать правильное использование СИЗ.

Выводы: обучение в бакалавриате должно соответствовать передовой практике использования СИЗ и включать практическое обучение, включающее правильные и безопасные методы.

Прогностическая ценность сверхэкспрессии ферментов, связанных с метаболизмом жирных кислот, при плоскоклеточном раке головы и шеи

Перепрограммирование метаболизма подвижных жизненных сил, соответствующего метаболизму липидов, является индикатором плоскоклеточного рака вершины и шеи (SCCHN). Тем не менее, остается неясным, влияет ли экспрессия белка, связанная с окислением жирных кислот (FAO) на выживаемость в SCCHN.

Мы стремились проанализировать экспрессию ферментов, связанных с ФАО, и определить ее корреляцию с клинико-патологическими переменными у пациентов с SCCHN. Иммуногистохимическая оценка (ИГХ) экспрессии белка, связанного с ФАО, вместе с карнитин-пальмитоилтрансферазой 1 (СРТ1), ацил-КоА-дегидрогеназой и синтазой жирных кислот (FAS) была проведена с использованием тканевых микрочипов из 102 резецированных опухолей SCCHN.

Выражения были классифицированы в соответствии с оценками IHC, и была решена статистическая принадлежность к клинико-патологическим компонентам. Относительно высокой экспрессии длинноцепочечной ацил-КоА-дегидрогеназы (LCAD) была защитная функция от смерти, связанной с раком (скорректированное отношение рисков (HR), 0,2; 95% доверительный интервал (CI), 0,05-0,87) после ковариации корректирование.

Возраст и медицинская стадия оставались объективными предикторами выживаемости (скорректированный HR, 1,75; 95% ДИ, 1,22–2,49 для возраста; скорректированный HR, 14,33; 95% ДИ, 1,89-108,60 для стадии III / IV).
Сверхэкспрессия ацил-CoA дегидрогеназы со средней длиной цепи и FAS коррелировала с высшей стадией опухоли (T3 / T4); тем не менее, ни один из этих компонентов не был объективным предиктором выживаемости.

Было повышено количество ферментов, связанных с ФАО, и сверхэкспрессия LCAD оказала защитное влияние на общую выживаемость у пациентов с более сильным SCCHN. Экспрессия ферментов, связанных с ФАО, может потребовать прогноза по результатам выживаемости при SCCHN.

 

Паклитаксел подавляет миграцию клеток злокачественной глиомы CD133 + U251 за счет снижения экспрессии гликолитических ферментов.

• Жизнеспособное метаболическое перепрограммирование (EMR) позволяет перестраивать последовательность метаболических генов и белков, когда опухолевые клетки адаптируются к своему микроокружению.

EMR характеризуется модификациями метаболического образца и промежуточных продуктов метаболизма, чтобы удовлетворить потребности опухолевых клеток в его или ее злокачественном разрастании и инфильтративном прогрессе.

• В текущем исследовании изучалась функция паклитаксела в низких дозах (PTX) в изменении диапазонов экспрессии ключевых генов и белков в процессе гликолиза в клетках глиомы CD133 + U251 и изучались связанные механизмы регуляции движения на молекулярном уровне.

Иммуномагнитные шарики CD133 были использованы для злокачественных клеток глиомы CD133 + U251, которые затем были разделены прямо на группу, подвергшуюся вредному лечению, и экспериментальную группу, обработанную 1, 2, 4 или 8 мкМ PTX в течение 72 часов.

• Пакет для подсчета клеток-8 (CCK-8) использовался для измерения пролиферации клеток U251. РНК и белок были извлечены из клеток злокачественной глиомы во всех группах, чтобы наблюдать за изменениями в диапазонах экспрессии ключевых гликолитических ферментов, соответствующих переносчику глюкозы 1 (GLUT1), пируваткиназе M (PKM) и лактатдегидрогеназе A (LDHA), используя количественная ПЦР с обратной транскрипцией и вестерн-блоттинг.

Для количественной оценки результатов разрешения РТХ на клетках U251 были проведены анализы миграции через лунки. Клетки глиомы CD133 + U251 удалялись эффективно.

• Клетки CD1133 + имели лучшую цену пролиферации по сравнению с клетками CD1133-. В клетках CD1133 +, обработанных PTX, дозозависимая скидка в пределах диапазонов экспрессии важных гликолитических ферментов GLUT1, PKM и LDHA была замечена в каждом диапазоне мРНК и белка.

Разрешение PTX дополнительно ингибировало миграцию клеток. Различия между управляющими и экспериментальными группами были статистически значимыми (P <0,05).

• Поскольку гликолиз выполняет незаменимую функцию в пролиферации и миграции клеток глиомы, подобных стволовым, PTX может ингибировать прогрессирование опухолевых клеток путем подавления диапазонов экспрессии генов и белков гликолитических ферментов в клетках глиомы CD133 +.

 

Human Dkk-1
MBS692271-5x002mg	MyBiosource	5x0.02mg	EUR 1325

Human DKK-1
HC67719	Antigenix America	10 µg	Ask for price

DKK-1 Protein, Human
UA040180	Starter Biotechnology Co Ltd	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 µg 10 µg 50 µg 100 µg 500 µg 1 mg

Dkk-1 (Human) ELISA Kit
EKA52037-5x96T	Biomatik Corporation	5x96T	Ask for price

Dkk-1 (Human) ELISA Kit
EKA52037-96T	Biomatik Corporation	96T	EUR 446.9

Human CellExp? DKK-1, Human Recombinant
7132-10	Biovision	each	EUR 333.6

Human CellExp? DKK-1, Human Recombinant
7132-50	Biovision	each	EUR 1358.4

Human Dkk-1 ELISA Kit
GWB-SKR221	GenWay Biotech	96 Tests	Ask for price

Human Dkk-1 ELISA KIT
E42EH-269	EnoGene	96T/48T	EUR 795

Human Dkk-1 ELISA Kit
E28L0566	EnoGene	96T	EUR 666.67

Human DKK-1 ELISA Kit
EK5390	SAB	96 tests	EUR 599
https://www.sabbiotech.com/g-138088-Human-DKK-1-ELISA-Kit-EK5390.html

DKK-1 ELISA KIT|Human
EF000090	Lifescience Market	96 Tests	EUR 826.8

Human Dkk-1 ELISA Kit
NR-E10156	Novatein Biosciences, Inc.	Ask for price Ask for price	96 Tests 96 Tests

Human DKK-1 ELISA kit
LF-EK50797	Abfrontier	1×96T	EUR 777.6

Human Dkk-1 ELISA Kit
SEKH-0144	Solarbio Life Science	Ask for price Ask for price	48 Tests 96 Tests

DKK-1 (HEK293-expressed), Human
HY-P7155A	MedChemExpress	50ug	EUR 1011.6

Human Dkk-3
MBS691794-0002mg	MyBiosource	0.002mg	EUR 300

Human Dkk-3
MBS691794-001mg	MyBiosource	0.01mg	EUR 450

Human Dkk-3
MBS691794-5x001mg	MyBiosource	5x0.01mg	EUR 1725

Human Dkk-2
MBS692245-0002mg	MyBiosource	0.002mg	EUR 300

Human Dkk-2
MBS692245-001mg	MyBiosource	0.01mg	EUR 450

Human Dkk-2
MBS692245-5x001mg	MyBiosource	5x0.01mg	EUR 1725

Human Dkk-2
MBS692272-0005mg	MyBiosource	0.005mg	EUR 250

Human Dkk-2
MBS692272-002mg	MyBiosource	0.02mg	EUR 360

Human Dkk-2
MBS692272-5x002mg	MyBiosource	5x0.02mg	EUR 1325

Human DKK-3
HC51274	Antigenix America	10 µg	Ask for price

Human DKK-2
HC51277	Antigenix America	10 µg	Ask for price

Human Dkk-1 Recombinant Protein
200-013	ReliaTech	20 µg	EUR 136.5
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein
200-013S	ReliaTech	5 µg	EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein
PROTO94907	BosterBio	Regular: 5ug	EUR 300
Description: Human Dkk-1 Recombinant Protein expressed in Baculovirus with His-tag. Sequence domain: 32-266aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

Recombinant Human DKK-1 Protein
PROTO94907-3	BosterBio	10ug	EUR 380.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Recombinant Human Dkk-1 Protein
RP01343	Abclonal	100μg	EUR 162.96
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway Show more

human Dkk-1 Recombinant Protein
100-407	ReliaTech	10 µg	EUR 196.35
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

human Dkk-1 Recombinant Protein
100-407S	ReliaTech	2 µg	EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1 (Human) LumiAb ELISA Kit
MBS9510975-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 4355

Dkk-1 (Human) LumiAb ELISA Kit
MBS9510975-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2225

Dkk-1 (Human) LumiAb ELISA Kit
MBS9510975-96StripWells	MyBiosource	96-Strip-Wells	EUR 500

Dkk-1 (Human) Sandwich ELISA Kit
OK-0326	Assay Biotech	1Kit	EUR 280
Description: Dkk-1 (Human) Colorimetric Sandwich ELISA Kit

Dkk-1 (Human) OmniKine ELISA Kit
MBS9502047-1x96Wells	MyBiosource	1x96Wells	EUR 500

Dkk-1 (Human) OmniKine ELISA Kit
MBS9502047-5x96Wells	MyBiosource	5x96Wells	EUR 2300

Human DKK-1 PicoKine ELISA Kit
MBS176546-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2755

Human DKK-1 PicoKine ELISA Kit
MBS176546-96StripWells	MyBiosource	96-Strip-Wells	EUR 600

Human Dickkopf-1(Dkk-1) ELISA kit
E22-HC074.48	EnoGene	48T	EUR 495

Human Dickkopf-1(Dkk-1) ELISA kit
E22-HC074.96	EnoGene	96T	EUR 595

Human DKK Antibody
E63C02401	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

Human DKK Antibody
MBS857428-01mg	MyBiosource	0.1mg	EUR 305

Human DKK Antibody
MBS857428-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

Human DKK Antibody
MBS857428-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

Human DKK Antibody
MBS857428-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

Human DKK Antibody
MBS857428-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

Human DKK-1 Recombinant Protein Lyophilized
IHUDKK1RLY2UG	Innovative research	each	EUR 341
Wet Ice
Description: Human DKK-1 Recombinant Protein Lyophilized

Human DKK-1 Recombinant Protein Lyophilized
MBS8431839-INQUIRE	MyBiosource	INQUIRE	Ask for price

Human DKK-1 ELISA kit (4×96T)
LF-EK50798	Abfrontier	4×96T	EUR 2641.2

Nori® Human DKK-1 ELISA Kit
GR106268	Genorise Scientific	96-well	EUR 461

Dkk-1
GT30000	Neuromics	50 ug	EUR 391.5

Dkk-1
MBS555901-005mg	MyBiosource	0.05mg	EUR 610

Dkk-1
MBS555901-5x005mg	MyBiosource	5x0.05mg	EUR 2590

OKAG00221-96W - Dkk-1 ELISA Kit (Human)
OKAG00221-96W	Aviva Systems Biology	1plate:12x8-WellMicrostrips	EUR 475
Dkk-1 ELISA Kit (Human)

OKRC00363-96W - Dkk-1 ELISA Kit (Human)
OKRC00363-96W	Aviva Systems Biology	96Wells	EUR 525
Dkk-1 ELISA Kit (Human)

Dkk-1, 32-266aa, Human, His tag, Baculovirus
MBS203274-001mg	MyBiosource	0.01mg	EUR 375

Dkk-1, 32-266aa, Human, His tag, Baculovirus
MBS203274-005mg	MyBiosource	0.05mg	EUR 1265

Dkk-1, 32-266aa, Human, His tag, Baculovirus
MBS203274-5x005mg	MyBiosource	5x0.05mg	EUR 5460

Human DKK Antibody-HRP
E63C02402	EnoGene	100ug/100ul	EUR 275
Description: Available in various conjugation types.

Human DKK Antibody-HRP
MBS857208-01mg	MyBiosource	0.1mg	EUR 345

Human DKK Antibody-HRP
MBS857208-5x01mg	MyBiosource	5x0.1mg	EUR 1410

DKK-3 ELISA KIT|Human
EF000091	Lifescience Market	96 Tests	EUR 826.8

Human Dkk-4 ELISA Kit
NR-E10158	Novatein Biosciences, Inc.	Ask for price Ask for price Ask for price	96 Tests 2x 96 Tests 4x 96 Tests

Human Dkk-3 ELISA Kit
NR-E10157	Novatein Biosciences, Inc.	Ask for price Ask for price	96 Tests 96 Tests

Human Dkk-3 ELISA Kit
SEKH-0145	Solarbio Life Science	Ask for price Ask for price	48 Tests 96 Tests

Recombinant Human DKK1 / Dkk-1 Protein (His tag)
MBS2546459-002mg	MyBiosource	0.02mg	EUR 315

Recombinant Human DKK1 / Dkk-1 Protein (His tag)
MBS2546459-01mg	MyBiosource	0.1mg	EUR 605

Recombinant Human DKK1 / Dkk-1 Protein (His tag)
MBS2546459-5x01mg	MyBiosource	5x0.1mg	EUR 2715

Recombinant Human DKK1/Dkk-1 Protein (N-His)
MBS2557306-001mg	MyBiosource	0.01mg	EUR 220

Recombinant Human DKK1/Dkk-1 Protein (N-His)
MBS2557306-005mg	MyBiosource	0.05mg	EUR 505

Recombinant Human DKK1/Dkk-1 Protein (N-His)
MBS2557306-5x005mg	MyBiosource	5x0.05mg	EUR 2270

Recombinant Human DKK1/Dkk-1 Protein (His Tag)
PKSH033697-10ug	Elabscience Biotech	10ug	EUR 178
> 95 % as determined by reducing SDS-PAGE.
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)
PKSH033697-50ug	Elabscience Biotech	50ug	EUR 523
> 95 % as determined by reducing SDS-PAGE.
Description: Human

Human DKK Antibody-BIOTIN
E63C02403	EnoGene	100ug/100ul	EUR 275
Description: Available in various conjugation types.

Human DKK Antibody-BIOTIN
MBS857030-01mg	MyBiosource	0.1mg	EUR 345

Human DKK Antibody-BIOTIN
MBS857030-5x01mg	MyBiosource	5x0.1mg	EUR 1410

Mouse anti Human DKK1/Dkk-1 Monoclonal Antibody
MBS2543267-006mL	MyBiosource	0.06mL	EUR 250

Mouse anti Human DKK1/Dkk-1 Monoclonal Antibody
MBS2543267-012mL	MyBiosource	0.12mL	EUR 370

Mouse anti Human DKK1/Dkk-1 Monoclonal Antibody
MBS2543267-02mL	MyBiosource	0.2mL	EUR 550

Human Dkk-2 Recombinant Protein
200-014	ReliaTech	20 µg	EUR 136.5
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Human Dkk-2 Recombinant Protein
200-014S	ReliaTech	5 µg	EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Human Dkk-3 Recombinant Protein
PROTQ9UBP4	BosterBio	Regular: 20ug	EUR 250
Description: Human Dkk-3 Recombinant Protein expressed in Baculovirus with His-tag. Sequence domain: 22-350aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

Recombinant Human Dkk-3 Protein
RP00209	Abclonal	10 μg	EUR 38.26
Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists . Dkk-3 is a secreted monomer expressed in many normal human tissues, most strongly in heart, brain and spi Show more

Recombinant Human Dkk-3 Protein
RP00355	Abclonal	10 μg	EUR 41.8

human Dkk-3 Recombinant Protein
100-408	ReliaTech	10 µg	EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-3 Recombinant Protein
100-408S	ReliaTech	2 µg	EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

 

 

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